Visceral Hyperalgesia

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Visceral Hyperalgesia

Visceral hyperalgesia refers to increased pain sensation in response to gastrointestinal sensory stimulus. In neonates with neurological impairments, gabapentin has been successfully used as a treatment for visceral hyperalgesia in neonates. The authors describe a preterm infant with myelomeningocele and persistent neuropathic pain that manifested as irritability, hypertonicity, poor weight gai...

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[Visceral hyperalgesia and chronic abdominal pain: diagnostic and therapeutic approach.].

BACKGROUND AND OBJECTIVES Chronic abdominal pain is one of the most frequent reasons for medical consultation. There is, however, no well-established protocol for its diagnostic approach and, most of the times, investigation becomes an expensive and invasive medical practice. This review aimed at explaining visceral pain pathophysiology and establishing diagnostic and therapeutic goals for thes...

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Electroacupuncture on Visceral Hyperalgesia - What Is Its Mechanism?

CC This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. *Correspondence: Jeong Eun Shin, MD Department of Internal Medicine, Dankook University ...

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Combinations of neurokinin receptor antagonists reduce visceral hyperalgesia.

The effect of selective neurokinin receptor (NKR) antagonists for the NK1R (SR140,333), NK2R (SR48,968), and NK3R (SR142,801) on the visceromotor response to noxious colorectal distension (CRD) was examined. NKR antagonists or vehicle were given intrathecally (i.th.) to rats made hyperalgesic by intracolonic instillation of zymosan or after intracolonic instillation of saline (control). Given a...

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Putative therapeutic targets in the treatment of visceral hyperalgesia.

The management of abdominal pain remains a major challenge for clinicians despite an explosion of knowledge regarding the physiology and pathophysiology of sensory neural circuits. Initial progress was made in the field of somatic pain and this provided broad hypotheses that could be tested in the field of visceral pain. The major advances in our understanding of basic mechanisms underlying vis...

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ژورنال

عنوان ژورنال: Child Neurology Open

سال: 2017

ISSN: 2329-048X,2329-048X

DOI: 10.1177/2329048x17693123